Journal
CHEMISTRYSELECT
Volume 4, Issue 8, Pages 2404-2408Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201900113
Keywords
C-H functionalization; DMF; Selectfluor; pyridines
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Funding
- Zhejiang Provincial Natural Science Foundation of China [LY19H300001]
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An efficient one-pot four-component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4-diarylsubstituted pyridines promoted by Selectfluor has been achieved. Symmetrical pyridines were obtained selectively when non-methyl ketones were used as the starting materials. Two C-C and C-N bonds are formed during the oxidative cyclization process.
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