Journal
CHEMISTRYSELECT
Volume 4, Issue 8, Pages 2320-2326Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201900128
Keywords
Copper; Three-component reaction; MCM-41; Imidazo[1,2-a]pyridine; Heterogeneous catalysis
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Funding
- National Natural Science Foundation of China [21462021]
- Key Laboratory of Functional Small Organic Molecule, Ministry of Education [KLFS-KF-201704]
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The heterogeneous cascade three-component reaction of 2-aminopyridines, aldehydes and terminal alkynes was achieved in toluene at 120 degrees C in the presence of 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized copper(I) complex [MCM-41-2 N-CuCl] (5 mol%) and copper(II) complex [MCM-41-2N-Cu(OTf)(2)] (5 mol%), yielding a wide variety of imidazo[1,2-a]pyridines in mostly good to excellent yields. These two heterogeneous copper catalysts can be facilely prepared via a simple procedure from readily available and inexpensive reagents, and recovered by filtration and recycled up to eight times with almost consistent activity.
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