4.4 Article

3D Printing Artificial Blood Vessel Constructs Using PCL/Chitosan/Hydrogel Biocomposites

Journal

CHEMISTRYSELECT
Volume 4, Issue 8, Pages 2387-2391

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201803740

Keywords

artificial; blood; vessel; biomaterials; huvecs; hydrogels; 3d printing

Funding

  1. Marmara University [SAG-B-090217-0036]

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The present paper aims to overcome the problems related to previous use of autologous grafts using available synthetic grafts. To examine the optimum of the ideal vessel-like constructs parameters are produced at 230 degrees C. At this production temperature, the elastic modulus values of the constructs ranges from 56 MPa to 174 MPa. The maximum cell proliferation is obtained from PCL/7wt.%CS/5wt.%H that is tested by mitochondrial dehydrogenase activity. The structures are visualized with all constructs after cell fixation by making use of the HUVEC cell line.

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