Journal
CHEMISTRYSELECT
Volume 4, Issue 12, Pages 3500-3504Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201900090
Keywords
Amide; C-N bond cleavage; Synthesis; Catalysts
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Funding
- National Key Research and Development Program of China [2016YFB0301501]
- National Natural Science Foundation of China [21776130]
- Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture [XTD1821, XTD1802]
- Topnotch Academic Programs Project of Jangsu Higher Education Institutions (TAPP)
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A novel method of the synthesis of tertiary aromatic amides from tertiary benzylamines with high atom utilization has been developed. The reaction undergoes a different mechanism, which is divided into two parts: firstly tertiary amine is decomposed (into benzaldehyde and secondary amine) via TBAI/TBHP-mediated C-N bond cleavage, then tertiary amide is generated through the oxidative amidation of the intermediates products (benzaldehyde and secondary amine). These two parts of reaction are integrated into a single operation, which provides moderate to excellent yields with a wide suabstrate scope.
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