Journal
CANCER MANAGEMENT AND RESEARCH
Volume 11, Issue -, Pages 2729-2737Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S189052
Keywords
lncRNA; GAS5; tumor suppressor; tumor
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Funding
- Programs Foundation of Ministry of Education of China [20120101120132]
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Long non-coding RNAs (lncRNAs) have shown potential as a biomarker in the diagnosis and prognosis in multiple cancers. LncRNAs are dysregulated in various cancers, playing either oncogenic or tumor suppressive roles. Emerging evidences have proved that the growth arrest-specific 5 (GAS5) lncRNA can function as a tumor suppressor in several cancers. LncRNA GASS is downregulated in many types of cancer, regulating cellular processes such as cell proliferation, apoptosis and invasion. The low level of GAS5 expression often elevates capacity of proliferation and predicts poorer prognosis in some cancers. This review aims to summarize the recent published literature on the biogenesis, regulation mechanism and function of GAS5 in different types of cancers and explore its potential for cancer diagnosis, prognosis and treatment.
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