Journal
ACS CENTRAL SCIENCE
Volume 5, Issue 5, Pages 796-807Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.9b00060
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Funding
- National Natural Science Foundation of China [81571813, 21874011, 21622608, 21821005]
- National Key R&D Program of China [2017YFA0207900]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB29040303]
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A novel cancer vaccine is developed by using Fe3O4 magnetic nanoclusters (MNCs) as the core and cancer cell membranes decorated with anti-CD205 as the cloak. Because of the superparamagnetism and magnetization of MNCs, it is first achieved for the magnetic retention of vaccine in the lymph nodes with a magnetic resonance imaging (MRI) guide, which opened the time window for antigen uptake by dendritic cells (DCs). Meanwhile, the camouflaged cancer cell membranes serve as a reservoir of various antigens, enabling subsequent multiantigenic response. Additionally, the decorated anti-CD205 direct more vaccine into CD8(+) DCs, facilitating the major histocompatibility complex (MHC) I cross-presentation. These unique advantages together lead to a great proliferation of T cells with superior clonal diversity and cytotoxic activity. As a result, potent prophylactic and therapeutic effects with few abnormalities are observed on five different tumor models. Therefore, such a cancer-derived magnetosome with the integration of various recent nanotechnologies successfully demonstrates its promise for safe and high-performance cancer vaccination.
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