Journal
OPTICA
Volume 6, Issue 6, Pages 702-708Publisher
OPTICAL SOC AMER
DOI: 10.1364/OPTICA.6.000702
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Funding
- H2020 Marie Sklodowska-Curie Actions (MSCA) (H2020-MSCA-ITN-2014) Mid-TECH grant [642661]
- Ministerio de Ciencia, Innovacion y Universidades (MICINN) [TEC2015-68234-R]
- Generalitat de Catalunya (CERCA Programme)
- Severo Ochoa Programme for Centres of Excellence in RD [SEV-2015-0522]
- European Social Fund (ESF) [BES-2016-079359]
- Fundacio Privada Cellex
- Marie Curie Actions (MSCA) [642661] Funding Source: Marie Curie Actions (MSCA)
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In this work we demonstrate, to the best of our knowledge, a novel wide field-of-view upconversion system, supporting upconversion of monochromatic mid-infrared (mid-IR) images, e.g., for hyperspectral imaging (HSI). An optical parametric oscillator delivering 20 ps pulses tunable in the 2.3-4 mu m range acts as a monochromatic mid-IR illumination source. A standard CCD camera, in synchronism with the crystal rotation of the upconversion system, acquires in only 2.5 ms the upconverted mid-IR images containing 64 kpixels, thereby eliminating the need for postprocessing. This approach is generic in nature and constitutes a major simplification in realizing video-frame-rate mid-IR monochromatic imaging. A second part of this paper includes a proof-of-principle study on esophageal tissues samples, from a tissue microarray, in the 3-4 mu m wavelength range. The use of mid-IR HSI for investigation of esophageal cancers is particularly promising as it allows for a much faster and possibly more observer-independent workflow than state-ofthe-art histology. Comparing histologically stained sections evaluated by a pathologist to images obtained by either Fourier transform IR or upconversion HSI based on machine learning shows great promise for further work pointing towards clinical translation using the presented mid-IR HSI upconversion system. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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