Journal
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
Volume 8, Issue 5, Pages 593-601Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jayao.2019.0010
Keywords
secondary neoplasms; meningiomas; children; brain tumors; irradiation; survivors
Categories
Funding
- Special State Grants for Health Research in the Department of Pediatrics and Adolescence, Oulu University Hospital, Finland
- Vare Foundation for Pediatric Cancer Research, Finland
- Foundation of Paivikki and Sakari Sohlberg, Finland
- Foundation of Arvo and Lea Ylppo, Finland
- Foundation for Pediatric Research, Finland
- Foundation of Emil Aaltonen, Finland
- Cancer Society of Finland
- Foundation of Thelma Makikyro, Finland
- Cancer Foundation of Northern Finland
- Foundation of Marta Donner, Finland
- Foundation of Alma and K.A. Snellman, Finland
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Purpose: Childhood brain tumors (CBTs) and their treatment increase the risk of secondary neoplasms (SNs). We studied the incidence of secondary craniospinal tumors with magnetic resonance imaging (MRI) screening in a national cohort of survivors of CBT treated with radiotherapy, and we analyzed the Finnish Cancer Registry (FCR) data on SNs in survivors of CBT with radiotherapy registered as a part of the primary tumor treatment. Methods: A total of 73 survivors of CBT participated in the MRI study (mean follow-up of 19 +/- 6.2 years). The incidence of SNs in a cohort of CBT patients (N = 569) was retrieved from the FCR (mean follow-up of 11 +/- 12.9 years). Brain tumors were diagnosed at age <= 16 years between the years 1970 and 2008 in the clinical study and the years 1963 and 2010 in the FCR population. Results: Secondary brain tumors, meningiomas in all and schwannoma in one, were found in 6 of the 73 (8.2%) survivors with a mean of 23 +/- 4.3 years after the diagnosis of the primary tumor. The cumulative incidence was 10.2% (95% confidence interval [CI] 3.9-25.1) in 25 years of follow-up. In the FCR data, the 25-year cumulative incidence of SNs was 2.4% (95% CI 1.3-4.1); only two brain tumors, no meningiomas, were registered. Conclusion: Survivors of CBT treated with radiotherapy have a high incidence of meningiomas, which are rarely registered in the FCR.
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