4.6 Review

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research

Journal

FRONTIERS IN NEUROLOGY
Volume 10, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2019.00332

Keywords

aging; hypertension; diabetes; hyperglycemia; obesity; comorbidity; mesenchymal; stroke

Funding

  1. Carlos III Research Institute, Spanish Ministry of Science and Innovation [PI16/01052, RD16/0019/0005]
  2. European Regional Development Fund (FEDER)
  3. RESSTORE project - European Commission under the H2020 program [681044]
  4. H2020 Societal Challenges Programme [681044] Funding Source: H2020 Societal Challenges Programme

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Stroke is a major health problem worldwide. It has been estimated that 90% of the population attributable risk of stroke is due to risk factors such as aging, hypertension, hyperglycemia, diabetes mellitus and obesity, among others. However, most animal models of stroke use predominantly healthy and young animals. These models ignore the main comorbidities associated with cerebrovascular disease, which could be one explanation for the unsuccessful bench-to-bedside translation of protective and regenerative strategies by not taking the patient's situation into account. This lack of success makes it important to incorporate comorbidities into animal models of stroke in order to study the effects of the various therapeutic strategies tested. Regarding cell therapy, the administration of stem cells in the acute and chronic phases has been shown to be safe and effective in experimental animal models of stroke. This review aims to show the results of studies with promising new therapeutic strategies such as mesenchymal stem cells, which are being tested in preclinical models of stroke associated with comorbidities and in elderly animals.

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