Journal
NANOMATERIALS
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/nano9040511
Keywords
mesoporous silica nanoparticle; protein delivery; controlled release; stimulus responsive MSN
Categories
Funding
- National Institutes of Health [1R15CA188847-01A1, 1R01AG054839-01A1]
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Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great physicochemical and thermal stability. In this review, we discuss the factors affecting the loading of protein into MSN and general strategies for targeted delivery and controlled release of proteins with MSN. Additionally, we also give an outlook for the remaining challenges in the clinical translation of protein-loaded MSNs.
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