Journal
JOURNAL OF IMMUNOLOGY RESEARCH
Volume 2019, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2019/2431617
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Funding
- Science and Technology Department of Guangdong Province [2017A050501010, 2016A050503023]
- Guangzhou Science, Technology and Innovation Commission [201807010042]
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Th17 activity has been implicated in systemic lupus erythematosus (SLE), which is a systemic autoimmune disease with a typical clinical manifestation of lupus nephritis (LN). Retinoic acid receptor-related orphan receptor gamma t (RORt) has been shown to be important for Th17 differentiation. In this study, we evaluated the inhibition of RORt activity by 3-acetyloxy-oleanolic acid (AOA), a small molecule isolated from the root of Symplocos laurina, a traditional herb belonging to South China. We demonstrated that AOA can inhibit RORt activity and prevent SLE pathogenesis in a pristane-induced LN model. The results showed that AOA decreased RORt transcription activity in a reporter assay and prevented Th17 differentiation in vitro. In vivo studies showed that AOA treatment decreased serum anti-dsDNA antibody and alleviated renal pathologic damage as well as antibody complex accumulation in the pristane-induced LN model. These results demonstrated that AOA can improve the clinical manifestation of LN, indicating potential application in SLE therapy.
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