Journal
GENES
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/genes10040318
Keywords
telomere maintenance; shelterin complex; end-protection problem; telomere damage; telomeric double strand breaks; telomere replication; alternative lengthening of telomeres
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Funding
- Associazione Italiana per la Ricerca sul Cancro, AIRC [19901]
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Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can sequester the chromosome terminus from DNA-end sensors and inhibition of key steps in the DNA damage response. While blocking the DNA damage response at chromosome ends, telomeres make wide use of many of its players to deal with exogenous damage and replication stress. This review focuses on the interplay between the end-protection functions and the response to DNA damage occurring inside the telomeric repeats, as well as on the consequences that telomere damage has on telomere structure and function.
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