Journal
FRONTIERS IN PHYSIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2019.00300
Keywords
preeclampsia; heme; hemopexin; alpha-1 microglobulin; aspirin
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Funding
- Erasmus + Program of the European Union [2013-0040]
- EVO research funding
- Academy of Finland
- Signe and Ane Gyllenberg Foundation
- Sigrid Juselius Foundation
- Finnish Medical Foundation
- Juho Vainio Foundation
- Novo Nordisk Foundation
- Jane and Aatos Erkko Foundation
- Paivikki and Sakari Sohlberg Foundation
- University of Helsinki Research Funds
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Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1 -microglobulin (A1M) in maternal plasma using enzyme-linked immunosorbent assay during the late second trimester of pregnancy in women with high and low risk of developing PE. In total 142 women were included in nested case-control study: 42 women diagnosed with PE and 100 controls (49 randomly selected high-risk and 51 low-risk controls). The concentration of plasma A1M in high-risk controls was higher compared to low-risk controls. Women with severe PE had higher plasma A1M levels compared to women with non-severe PE. In conclusion, the concentration of plasma A1M is increased in the late second trimester in high-risk controls, suggesting activation of endogenous protective system against oxidative stress.
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