Journal
FRONTIERS IN PHYSIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2019.00370
Keywords
ubiquitin; E3 ligase; cancer; inhibitor; HECT regulations
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Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC-IG) [IG19875]
- Italian Ministry of Education, Universities and Research [PRIN 20152CB22L]
- CARIPLO [2017-0746]
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Ubiquitination plays a pivotal role in several cellular processes and is critical for protein degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination cascade, responsible for substrate recognition. In order to achieve selectivity and specificity on their substrates, HECT E3 enzymes are tightly regulated and exert their function in a spatially and temporally controlled fashion in the cells. These characteristics made HECT E3s intriguing targets in drug discovery in the context of cancer biology.
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