Journal
BIOMATERIALS
Volume 42, Issue -, Pages 78-86Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.11.048
Keywords
Fullerenol; Anti-aging; Caenorhabditis elegans; Lifespan; DAF-16; Insulin/IGF-1 pathway
Funding
- National Basic Research Program of China (973 Program) from the Ministry of Science and Technology [2011CB933401, 2012CB934003]
- National Natural Science Foundation of China [21320102003, 11425520, 31271480]
- International Science & Technology Cooperation Program of China, Ministry of Science Technology of China [2013DFG32340, 2014DFG52500]
- Changjiang Scholar and Innovative Research Team in University [IRT13049]
Ask authors/readers for more resources
Fullerene derivatives have attracted extensive attention in biomedical fields and polyhydroxyl fullerene (fullerenol), a water-soluble fullerene derivative, is demonstrated as a powerful antioxidant. To further assess their anti-aging and anti-stress potential, we employed Caenorhabditis elegans (C elegans) as a model organism to evaluate the effects of fullerenol on the growth, development, behavior and anti-stress ability in vivo. The data show that fullerenol has no obviously toxic effect on nematodes and can delay C elegans aging progress under normal condition. Further studies demonstrate that fullerenol attenuates endogenous levels of reactive oxygen species and provides protection to C elegans under stress conditions by up-regulating stress-related genes in a DAF-16 depend manner and improving lifespan. In summary, our data suggest that fullerenol might be a safe and reasonable anti-aging candidate with great potential in vivo. (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available