Journal
APOPTOSIS
Volume 22, Issue 1, Pages 86-97Publisher
SPRINGER
DOI: 10.1007/s10495-016-1314-6
Keywords
Advanced oxidation protein production (AOPPs); Oxidative stress; Apoptosis; PARP-1; Chondrocytes; Rheumatoid arthritis
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Funding
- National Natural Science Foundation of China [81272042]
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This study aimed to investigate the effect of AOPPs on apoptosis in human chondrocytes. Chondrocytes were treated with AOPPs. Cell death, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, reactive oxygen species (ROS) generation, and the expression of apoptotic proteins were detected in vitro. AOPPs levels were detected by colorimetric method. The results in vitro demonstrated that AOPPs induced cell death in human chondrocyte through a redox-dependent pathway, including RAGE-mediated, NADPH oxidase-dependent ROS generation, and poly (ADP-ribose) polymerase-1 (PARP-1) activation. Targeting AOPPs-induced cellular mechanisms might emerge as a promising therapeutic option for patients with RA.
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