Journal
APOPTOSIS
Volume 22, Issue 3, Pages 325-356Publisher
SPRINGER
DOI: 10.1007/s10495-016-1335-1
Keywords
Natural compounds; Autophagy; Disease; Drug therapy
Categories
Funding
- National Natural Science Foundation of China (NSFC) [31270399, 81603275]
- Key Projects of the National Science and Technology Pillar Program [2012BAI30B02]
- Fund of the Educational Department of Liaoning Province [L2011177]
- Liaoning Baiqianwan Talents Program [2013921043]
- Liaoning Province Natural Science Foundation [201602689]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of Shenyang Pharmaceutical University [GGJJ2015103]
- Career Development Program for Young and Middle-aged Teachers of Shenyang Pharmaceutical University [ZQN2015015]
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Natural compounds derived from living organisms are well defined for their remarkable biological and pharmacological properties likely to be translated into clinical use. Therefore, delving into the mechanisms by which natural compounds protect against diverse diseases may be of great therapeutic benefits for medical practice. Autophagy, an intricate lysosome-dependent digestion process, with implications in a wide variety of pathophysiological settings, has attracted extensive attention over the past few decades. Hitherto, accumulating evidence has revealed that a large number of natural products are involved in autophagy modulation, either inducing or inhibiting autophagy, through multiple signaling pathways and transcriptional regulators. In this review, we summarize natural compounds regulating autophagy in multifarious diseases including cancer, neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and immune diseases, hoping to inspire further investigation of the underlying mechanisms of natural compounds and to facilitate their clinical use for multiple human diseases.
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