Journal
ELIFE
Volume 8, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.40541
Keywords
-
Categories
Funding
- Wellcome [203139/Z/16/Z, WT100973AIA, 105238/Z/14/Z, 103184/Z/13/Z, 105651/Z/14/Z]
- Bettencourt Schueller Foundation
- Agence Nationale de la Recherche [ANR-10-EQPX-15]
- Medical Research Council [MR/P024955/1, G0902373]
- Biotechnology and Biological Sciences Research Council [BB/N019814/1]
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek [452-13-015]
- BBSRC [BB/H016902/1, BB/N019814/1] Funding Source: UKRI
- MRC [G0600994, G0902373, MR/P024955/1] Funding Source: UKRI
- Wellcome Trust [105651/Z/14/Z, 105238/Z/14/Z, 103184/Z/13/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation technique. To date, investigations report short-lived neuromodulatory effects, but to deliver on its full potential for research and therapy, ultrasound protocols are required that induce longer-lasting 'offline' changes. Here, we present a TUS protocol that modulates brain activation in macaques for more than one hour after 40 s of stimulation, while circumventing auditory confounds. Normally activity in brain areas reflects activity in interconnected regions but TUS caused stimulated areas to interact more selectively with the rest of the brain. In a within-subject design, we observe regionally specific TUS effects for two medial frontal brain regions - supplementary motor area and frontal polar cortex. Independently of these site-specific effects, TUS also induced signal changes in the meningeal compartment. TUS effects were temporary and not associated with microstructural changes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available