Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 8, Issue 6, Pages 840-843Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201900079
Keywords
Cycloisomerization; Palladium-Catalyzed; (Z)-1-Iodo-1; 6-diene; 3-Aza-bicyclo[4; 1; 0]hept-2-ene; Cascade reaction
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Funding
- Shandong Provincial Natural Science Foundation [ZR2018MB008, ZR2018MB012]
- National Natural Science Foundation of China [21671121]
- Shandong Provincal Key Research and Development program of China [2017GGX20131]
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A Pd-catalyzed cycloisomerization of (Z)-1-iodo-1,6-dienes was developed to construct 3-aza-bicyclo[4.1.0]hept-2-enes bearing substitutions at C1/C5. A wide array of (Z)-1-iodo-1,6-dienes could be converted to the desired compounds efficiently. On the basis of mechanistic studies, two pathways were proposed, in which compound alkyl iodide derivatives formed by reductive elimination of Csp(3)-Pd-I was proved to be a possible intermediate.
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