Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 47, Issue 1, Pages 1610-1616Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2019.1594860
Keywords
AuNPs; Strychni Semen; KMCH-1 cells; cholangiocarcinoma cell
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Funding
- National Natural Science Foundation of China [81660399, 81860423]
- Innovative Research Team Project of Yunnan Province [2015HC033]
- Yunnan Provincial Academician Workstation of Xiaoping Chen [2017IC018]
- Breeding Program for Major Scientific and Technological Achievements of Kunming Medical University [CGYP201607]
- Medical Leading Talent Project of Yunnan Province [L201622]
- Yunnan Provincial Clinical Center of Hepato-biliary-pancreatic Diseases
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Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all the way through an environment-friendly approach. Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural environment. Amalgamation of nanoparticles by means of plant extract is alternate conservative methods. In the present study, we equipped gold nanoparticles (AuNPs) from Strychni semen; displayed as a less toxic and environment-friendly. Integration of AuNPs was famed by UV-absorbance which displays peak values. Moreover, high-resolution transmission electron microscopy (HR-TEM), energy dispersive X-ray analysis (EDX) and atomic force microscopy (AFM) substantiate the shape of the AuNPs in the combined materials. FTIR results exhibit the active molecules positioned in the flat surface of the AuNPs. Similarly, the anticancer effectiveness of AuNPs is considered in KMCH-1 cells. Also, AuNPs successfully aggravate cytotoxicity and apoptosis by conjugating apoptotic gene expressions in KMCH-1 cells. Eventually, our results confirm the synthesis of AuNPs from Strychni Semen shows anticancer effects with environment-friendly manner.
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