Journal
ADVANCED OPTICAL MATERIALS
Volume 7, Issue 15, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adom.201900229
Keywords
NIR-II fluorescence imaging; organic small-molecule probes; tumor imaging; twisted intramolecular charge transfer
Categories
Funding
- NSFC [81773674, 81573383]
- NSFHP [2017CFA024, 2017CFB711, 2016ACA126]
- Shenzhen Science and Technology Research Grant [JCYJ20170303170809222]
- Office of Science (BER)
- U.S. Department of Energy [DE-SC0008397]
- NIH ICMIC grant [P50 CA114747]
- Fundamental Research Funds for the Central Universities
- Health Commission of Hubei Province Scientific Research Project [WJ2019M177, WJ2019M178]
- Tibet Autonomous Region Science and Technology Plan Project Key Project [XZ201901-GB-11]
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Traditional luminescent materials including fluorescent probes suffer from notorious aggregation-caused quenching in aqueous solutions. Although several approaches such as the aggregation-induced emission effect have been developed, it remains a significant challenge to identify an effective and efficient strategy to resolve this issue. Herein, quaternary ammonium salts Q8PBn and Q8PNap as a novel class of bright near infrared window II (NIR-II, 1000-1700 nm) probes are designed and synthesized, and the twisted intramolecular charge transfer formation at the excited state can be effectively suppressed for the newly designed probes. Furthermore, Q8PNap complexation with fetal bovine serum (Q8PNap/FBS) significantly increases the quantum yield by approximate to 32-fold compared with PEGylated tertiary amine Q8P, and Q8PNap/FBS is successfully used to achieve high spatial and temporal resolution imaging of hind limb vasculature, lymphatic system, and small tumor metastasis, as well as precise NIR-II imaging-guided tumor and lymph node surgery in small animal models for the first time.
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