Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 8, Issue 9, Pages 971-982Publisher
WILEY
DOI: 10.1002/sctm.18-0132
Keywords
Bone marrow-derived mesenchymal stem cells; Anterior cruciate ligament; Decellularized allograft; Semitendinous tendon
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Funding
- National Natural Science Foundation of China [81301547]
- Guangdong Provincial Science and Technology Grant [2015A030401017]
- Health and Family Planning Commission of Shenzhen Municipality [SZBC2017022]
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As a regular adoptable material for anterior cruciate ligament (ACL) reconstruction, free tendon allograft exhibits unsatisfactory outcomes, such as retarded ligamentization and tendon-bone integration. The application of bone marrow-derived mesenchymal stem cells (BMSCs), as well as a decellularized free tendon allograft developed by our group, was proven to be effective in improving ACL reconstruction results. This study aimed to investigate the efficacy and feasibility of decellularized allogenic semitendinous tendon (ST) combined with autologous BMSCs used as a substitute to free tendon allograft in a rabbit model. This study finally shows that the decellularized allogenic ST combined with autologous BMSCs could significantly improve ACL reconstruction results compared with allograft. Stem Cells Translational Medicine 2019;8:971&982
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