Journal
PLOS BIOLOGY
Volume 17, Issue 4, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.3000224
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Funding
- National Key Research and Development Program of China [2018YFA0107703]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16010503]
- National Natural Science Foundation of China [31871502, 31722036]
- R&D Program of China [2018YFC2000100, 2017YFC1001302]
- CAS Strategic Priority Research Program [XDB32060000]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX05]
- Shanghai City Committee of science and technology project [18411953700, 18JC1410100]
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During the second World Summit of Human Gene Editing, Jiankui He presented the gene-editing project that led to the birth of two baby girls with man-made C-C chemokine receptor type 5 (CCR5) mutations. This extremely irresponsible behavior violated the ethical consensus of scientists all over the world. His presentation revealed a troubling lack not only of basic medical ethics but also of the requisite understanding of genetics and gene editing. Here, we review the rationale and design of his experiment along with the presented data, and provide our scientific criticism of this misconduct.
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