Journal
OPEN BIOLOGY
Volume 9, Issue 5, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsob.190049
Keywords
metabolic engineering; biofuels; cell factory; Saccharomyces cerevisiae
Categories
Funding
- Swedish Foundation for Strategic Research
- Novo Nordisk Foundation [NNF10CC1016517]
- Knut and Alice Wallenberg Foundation
Ask authors/readers for more resources
The yeast Saccharomyces cerevisiae is a widely used cell factory for the production of fuels and chemicals, in particular ethanol, a biofuel produced in large quantities. With a need for high-energy-density fuels for jets and heavy trucks, there is, however, much interest in the biobased production of hydrocarbons that can be derived from fatty acids. Fatty acids also serve as precursors to a number of oleochemicals and hence provide interesting platform chemicals. Here, we review the recent strategies applied to metabolic engineering of S. cerevisiae for the production of fatty acid-derived biofuels and for improvement of the titre, rate and yield (TRY). This includes, for instance, redirection of the flux towards fatty acids through engineering of the central carbon metabolism, balancing the redox power and varying the chain length of fatty acids by enzyme engineering. We also discuss the challenges that currently hinder further TRY improvements and the potential solutions in order to meet the requirements for commercial application.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available