Journal
CELL REPORTS
Volume 27, Issue 1, Pages 11-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.03.034
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Funding
- NIH [F31 GM115177, R01 GM060574, R35 GM127338]
- AAUW
- Boston University UROP
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2016M3C7A1905391, NRF-2016R1C1B3006969, NRF-2018R1A4A1020922]
- [NSF-REUBIO-1659605]
- National Research Foundation of Korea [2016M3C7A1905391] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Cell death is a fundamental aspect of development, homeostasis, and disease; yet, our understanding of non-apoptotic forms of cell death is limited. One such form is phagoptosis, in which one cell utilizes phagocytosis machinery to kill another cell that would otherwise continue living. We have previously identified a non-autonomous requirement of phagocytosis machinery for the developmental programmed cell death of germline nurse cells in the Drosophila ovary; however, the precise mechanism of death remained elusive. Here, we show that lysosomal machinery acting in epithelial follicle cells is used to non-autonomously induce the death of nearby germline cells. Stretch follicle cells recruit V-ATPases and chloride channels to their plasma membrane to extracellularly acidify the germline and release cathepsins that destroy the nurse cells. Our results reveal a role for lysosomal machinery acting at the plasma membrane to cause the death of neighboring cells, providing insight into mechanisms driving non-autonomous cell death.
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