Journal
ANTIVIRAL RESEARCH
Volume 130, Issue -, Pages 46-49Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2016.03.013
Keywords
Flavivirus; NITD008; Antiviral; Nucleoside analog; Tick-borne
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Funding
- CDC core funding
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There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity. Published by Elsevier B.V.
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