4.5 Article

Bacillus licheniformis Zhengchangsheng® attenuates DSS-induced colitis and modulates the gut microbiota in mice

Journal

BENEFICIAL MICROBES
Volume 10, Issue 5, Pages 543-553

Publisher

WAGENINGEN ACADEMIC PUBLISHERS
DOI: 10.3920/BM2018.0122

Keywords

Bacillus licheniformis; inflammatory bowel disease; dysbiosis; Bacteroidetes; endotoxin; intestinal barrier function

Funding

  1. Nature Science Foundation of Liaoning Province, China [2015020262]
  2. Department of Education, Liaoning Province, China [L2016003]
  3. China Postdoctoral Science Foundation [2016M601317, 2018T110225]
  4. National Natural Science Foundation of China [81502737, 81472891]
  5. Liaoning Provincial Program for Top Discipline of Basic Medical Sciences, China

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Human inflammatory bowel disease (IBD) and experimental colitis models in mice are associated with shifts in gut microbiota composition, and several probiotics are widely used to improve gastrointestinal health. Here, we investigated whether the probiotic Bacillus licheniformis Zhengchangsheng (R) (BL) ameliorates dextran sulphate sodium (DSS)-induced colitis through alteration of the gut microbiota. Experimental colitis was induced in BALB/C mice by dissolving 3% DSS in their drinking water for 7 days, which were gavaged with 0.2 ml phosphate-buffered saline or BL (3x10(7) cfu/ml) once a day. Administration of BL attenuated several effects of DSS-induced colitis, including weight loss, increased disease activity index, and disrupted intestinal barrier integrity. In addition, BL mitigated the reduction in faecal microbiota richness in DSS treated mice. Interestingly, BL was found to reduce the elevated circulating endotoxin level in mice with colitis by modulating the microbial composition of the microbiota, and this was highly associated with a proportional decrease in gut Bacteroidetes. Our results demonstrate that BL can attenuate DSS-induced colitis and provide valuable insight into microbiota interactions during IBD.

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