Journal
NUTRIENTS
Volume 11, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/nu11040894
Keywords
developmental origins of health and disease (DOHaD); gut microbiota; non-communicable disease; nutrient-sensing signal; nutrition; oxidative stress; pregnancy; reprogramming
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Funding
- Ministry of Science and Technology, Taiwan [MOST 107-2314-B-182-045-MY3]
- Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8H0831, CMRPG8J0251]
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Maternal nutrition plays a decisive role in developmental programming of many non-communicable diseases (NCDs). A variety of nutritional insults during gestation can cause programming and contribute to the development of adult-onset diseases. Nutritional interventions during pregnancy may serve as reprogramming strategies to reverse programming processes and prevent NCDs. In this review, firstly we summarize epidemiological evidence for nutritional programming of human disease. It will also discuss evidence from animal models, for the common mechanisms underlying nutritional programming, and potential nutritional interventions used as reprogramming strategies.
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