Journal
NEUROSCIENCE BULLETIN
Volume 35, Issue 5, Pages 921-933Publisher
SPRINGER
DOI: 10.1007/s12264-019-00388-3
Keywords
Microglia; Inflammation; Ischemic stroke; Signaling pathways
Categories
Funding
- National Natural Science Foundation of China [81571132, 81873743, 81801223]
- Fundamental Research Funds for the Central Universities, China [2017KFYXJJ107, 2017KFYXJJ124]
- National Institutes of Health, USA [R01NS088627]
Ask authors/readers for more resources
Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However, increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes, and endothelial cells within the brain parenchyma and the neurovascular unit.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available