Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 60, Issue 7, Pages 4351-4354Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00550-16
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Funding
- HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [R21AI117338, R01AI090155]
- National Natural Science Foundation of China (NSFC) [81572032]
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Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST25 isolates were identical (all pMCR1-IncX4), belonging to the IncX4 incompatibility group, while the plasmid from an E. coli ST2085 isolate (pMCR1-IncI2) belongs to the IncI2 group. A nearly identical 2.6-kb mcr-1-pap2 element was found to be shared by all mcr-1-carrying plasmids.
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