Journal
NATURE COMMUNICATIONS
Volume 10, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-019-09173-2
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Funding
- Pershing Square Sohn Prize by the Pershing Square Sohn Cancer Research Alliance
- Damon Runyon-Rachleff Innovation Award [DRR-29-14]
- NIH [R01 EB017748, R01 CA222836, K08 CA16396]
- MSKCC Center for Molecular Imaging & Nanotechnology (CMINT) and Technology Development Grants
- MSKCC NIH Core Grant [P30-CA008748]
- DST-SERB [ECR/2016/000672]
- Science and Engineering Research Board (SERB) [PDF/2016/002712]
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Recently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like spectra. As current Raman scanners rely on a slow, point-by-point spectrum acquisition, there is an unmet need for faster imaging to cover a clinically relevant area in real-time. Herein, we report the rational design and optimization of fluorescence-Raman bimodal nanoparticles (FRNPs) that synergistically combine the specificity of Raman spectroscopy with the versatility and speed of fluorescence imaging. DNA-enabled molecular engineering allows the rational design of FRNPs with a detection limit as low as 5 x 10(-15) M. FRNPs selectively accumulate in tumor tissue mouse cancer models and enable real-time fluorescence imaging for tumor detection, resection, and subsequent Raman-based verification of clean margins. Furthermore, FRNPs enable highly efficient image-guided photothermal ablation of tumors, widening the scope of the NPs into the therapeutic realm.
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