Journal
EPIGENOMICS
Volume 11, Issue 9, Pages 1056-1073Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2018-0184
Keywords
circular RNA; gene expression; osteogenic differentiation; SCAPs
Categories
Funding
- National Natural Science Foundation of China [81600822, 81873707]
- Medical Talent Project of Jiangsu Province [ZDRCA2016086]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) [2018-87]
- Science and Technology Development Project of Jiangsu Province [BE2017731]
Ask authors/readers for more resources
Aim: This study aimed to investigate the distinct expression pattern of circular RNAs (circRNAs) in stem cells from apical papilla (SCAPs) during osteogenesis. Materials & methods: Isolated SCAPs were cultured in growth medium or osteogenic medium, respectively. Total RNA was extracted and submitted to RNA-sequencing. Expression profiles of circRNAs and constructed circRNA-miRNA-mRNA networks were determined. Results: A total of 333 unregulated circRNAs and 317 downregulated circRNAs in osteogenic differentiation were detected. Bioinformatics analysis identified that several biological pathways may be associated with osteogenic differentiation of SCAPs. Moreover, ten circRNAs, 21 miRNAs and 19 mRNAs were selected to construct competing endogenous RNA networks. Conclusion: This study revealed that expression profiles of circRNAs were significantly altered and specific circRNAs might function as competing endogenous RNAs in SCAPs during osteogenic differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
