Journal
EPIGENOMICS
Volume 11, Issue 6, Pages 581-586Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2018-0139
Keywords
AluY families; BS-OLE assay; DNA methylation; psychiatric disorders; short terminal repeat retrotransposons
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Funding
- Guangdong-Hong Kong Technology Cooperation Funding Scheme of the Guangdong Science and Technology Foundation [2017A050506026]
- National Natural Science Foundation of China [8167133, 81371475]
- National Key Research and Development Program of China [2016YFC1201800]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT 16R37]
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Aim: To study DNA methylation patterns of AluY subfamilies in schizophrenia (SCZ) and bipolar disorder (BPD). Patients & methods: A bisulfite conversion-specific one-label extension method was employed to detect the AluY subfamily methylation levels of peripheral blood DNA from 92 SCZ patients, 99 BPD patients and 92 controls. Results: Hypermethylation of the AluY A1 and A2 CpG sites in BPD patients and hypomethylation of A3 CpG site in both of BPD and SCZ patients, and opposite age-dependent methylation alterations between SCZ and controls. Conclusion: The differentially altered DNA methylation patterns of the AluY families between BPD and SCZ suggest the role of DNA methylation in the pathogenesis of these major psychiatric disorders.
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