Journal
BIOFABRICATION
Volume 11, Issue 3, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1758-5090/ab15ca
Keywords
3D bioprinting; nanocomposite hydrogels; scaffolds; cell adhesion; cell migration
Funding
- Deutsche Forschungsgemeinschaft [KE1577/7-2]
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In this study we describe the first example of 3D bioprinted triphasic chiral nanocomposite (NC) hydrogels/scaffolds to simulate the complex 3D architecture, nano/micro scale topography, and chiral nature of extracellular matrix. These multifunctional constructs are prepared using a 3D bioprinting technique and are composed of three connected hydrogels/scaffolds, two of which are loaded with nanomaterials functionalized with opposite enantiomers of a biomolecule. With these constructs, we direct the migration of cells toward the part of the triphasic chiral NC hydrogels/scaffolds containing the cells' preferred biomolecule enantiomer.
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