Journal
VIRUSES-BASEL
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/v11060495
Keywords
norovirus entry; CD300lf; JAM-A; bile salts; histo-blood group antigens; murine norovirus; viral tropism
Categories
Funding
- NIH NIAID [K08 AI128043]
- Burroughs Wellcome Fund Career Award for Medical Scientists
- Rudolph J. Anderson Award
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Human norovirus is a major human pathogen causing the majority of cases of viral gastroenteritis globally. Viral entry is the first step of the viral life cycle and is a significant determinant of cell tropism, host range, immune interactions, and pathogenesis. Bile salts and histo-blood group antigens are key mediators of norovirus entry; however, the molecular mechanisms by which these molecules promote infection and the identity of a potential human norovirus receptor remain unknown. Recently, there have been several important advances in norovirus entry biology including the identification of CD300lf as the receptor for murine norovirus and of the role of the minor capsid protein VP2 in viral genome release. Here, we will review the current understanding about norovirus attachment and entry and highlight important future directions.
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