Journal
VIRUSES-BASEL
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/v11050466
Keywords
herpes simplex virus 1; ACV-resistant strains; amentoflavone; cofilin; F-actin dynamic
Categories
Funding
- National Natural Science Foundation of China [81573471, 81603341, 81872908]
- Key Laboratory of Virology of Guangzhou [201705030003]
- Guangzhou Major program of the Industry-University-Research collaborative innovation [201604020178]
- Scientific Research Foundation of Shenzhen University [2018021]
Ask authors/readers for more resources
Infection of Herpes simplex virus 1 (HSV-1) induces severe clinical disorders, such as herpes simplex encephalitis and keratitis. Acyclovir (ACV) is the current therapeutic drug against viral infection and ACV-resistant strains have gradually emerged, leading to the requirement for novel antiviral agents. In this study, we exhibited the antiviral activity of amentoflavone, a naturally occurring biflavonoid, toward HSV-1 and ACV-resistant strains. Amentoflavone significantly inhibited infection of HSV-1 (F strain), as well as several ACV-resistant strains including HSV-1/106, HSV-1/153 and HSV-1/Blue at high concentrations. Time-of-drug-addition assay further revealed that amentoflavone mainly impaired HSV-1 early infection. More detailed study demonstrated that amentoflavone affected cofilin-mediated F-actin reorganization and reduced the intracellular transportation of HSV-1 from the cell membrane to the nucleus. In addition, amentoflavone substantially decreased transcription of viral immediate early genes. Collectively, amentoflavone showed strong antiviral activity against HSV-1 and ACV-resistant strains, and amentoflavone could be a promising therapeutic candidate for HSV-1 pathogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available