Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 60, Issue 5, Pages 3202-3206Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00152-16
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Funding
- One Hundred Talents Program of the Chinese Academy of Sciences
- Key Program of the Chinese Academy of Sciences [KJZD-EW-L02]
- National Natural Science Foundation of China [81572037]
- State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University [2015SKLRD-K01, 2014SKLRD-O06]
- Chinese Academy of Sciences-Commonwealth Scientific and Industrial Research Organization Joint Grant [154144KYSB20150045]
- Guangzhou Municipal Industry and Research Collaborative Innovation Program [201508020248]
- Guangzhou Municipal Clinical Medical Center Program [155700012]
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We expressed the wild-type rplC and mutated rplC (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role of rplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) against the recombinant mycobacteria with overexpressed rplC mutation (Cys154Arg) was found, suggesting the rplC gene is a determinant of bacillary susceptibilities to LZD and PNU.
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