Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 60, Issue 10, Pages 6381-6385Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00941-16
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- Melinta Therapeutics, Inc.
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Delafloxacin, an investigational anionic fluoroquinolone, is active against a broad range of Gram-positive and Gram-negative bacteria. In this study, 200 Streptococcus pneumoniae (plus 30 levofloxacin-resistant isolates), 200 Haemophilus influenzae, and 100 Moraxella catarrhalis isolates selected primarily from the United States (2014) were tested against delafloxacin and comparator agents. Delafloxacin was the most potent agent tested. MIC50 and MIC90 values against all S. pneumoniae isolates were 0.008 and 0.015 mu g/ml. Delafloxacin susceptibility was not affected by beta-lactamase status against H. influenzae and M. catarrhalis.
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