Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 60, Issue 8, Pages 5047-5050Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00168-16
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Funding
- HHS | National Institutes of Health (NIH) [1R56AI102503-0A1]
- regular federal budget of the Ministry of Health of Argentina
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Klebsiella pneumoniae strains producing K. pneumoniae carbapenemase (KPC) cause serious infections in debilitated and immunocompromised patients and are associated with prolonged hospital stays and increased mortality rates. Daptomycin is a lipopeptide used against Staphylococcus aureus infection and considered inactive against Gram-negative bacteria. We investigated the effectiveness of a daptomycin-meropenem combination by synergy kill curve and a pharmacokinetic/pharmacodynamic model. The combination may represent a novel therapeutic strategy against infections caused by KPC-producing K. pneumoniae strains.
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