Journal
VIRUS RESEARCH
Volume 265, Issue -, Pages 115-121Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2019.03.014
Keywords
HIV cell-to-cell transmission; HIV latency; Virological synapse; Infectious synapse; Dendritic cells; CD4 T cells; Resting CD4 T cells
Categories
Funding
- NIH-NIAID [AI138960, AI097117]
- Providence/Boston Center for AIDS Research [P30-AI042853]
Ask authors/readers for more resources
HIV-1 spreads through both the release of cell-free particles and by cell-to-cell transmission. Mounting evidence indicates that cell-to-cell transmission is more efficient than cell-free transmission of particles and likely influences the pathogenesis of HIV-1 infection. This mode of viral transmission also influences the generation and maintenance of the latent reservoir, which represents the main obstacle for curing the infection. In this review we will discuss general cell contact-dependent mechanisms that HIV-1 utilizes for its spread and the evidence pointing to cell-to-cell transmission as a mechanism for the establishment and maintenance of latent infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available