Journal
TRIALS
Volume 20, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13063-019-3360-1
Keywords
Transcranial direct current stimulation; Mild cognitive impairment; Home-based; Cross-over study; Brain stimulation
Categories
Funding
- Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI17C1934]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning, Republic of Korea [2016R1C1B2010739]
- Korean Mental Health Technology R&D Project grant - Ministry of Health & Welfare, Republic of Korea [HM15C0995]
- Woo Young ryoul research grant of Yonsei University College of Medicine [6-2015-0174]
- National Research Foundation of Korea [2016R1C1B2010739] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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BackgroundThe possible effect of transcranial direct current stimulation (tDCS) in improving cognitive function is clear from studies involving pre-dementia stage mild cognitive impairment (MCI). However, the application of tDCS in actual clinical practice entails repeated hospital visits almost every day for treatment. The objective of this study is to confirm the possibility of self-application of tDCS at home by elderly patients with declined cognitive function and the significant clinical effect of tDCS administered at home.Methods/designThis study will be conducted in 20 elderly people aged 60 to 80years with complaints of subjective memory impairment while maintaining general functions with limited activities of daily living. This study involves a cross-over design that will include 2-week active or sham stimulation of both dorsolateral prefrontal cortexes (left, anode; right, cathode) randomly with a 2-week wash-out phase. Changes in cognitive function will be evaluated using visual recognition tasks and neuropsychological tests. In this study, tDCS will be carried out by each patient at his/her home and its safety and suitability will be evaluated.DiscussionIn this study, patients will apply a portable tDCS, developed for home use, for more than 2weeks. Such studies can contribute to the use of tDCS as a realistic therapy. In addition, the utility of home-based tDCS will be confirmed by application of tDCS at home by the elderly with declined cognitive function. Furthermore, confirmation of tDCS as a significant therapeutic method can facilitate treatment of Alzheimer's dementia at an early stage, including MCI.Trial registrationClinical Research Information Service (CRIS), KCT0002721. Registered on 9 March 2018.
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