Journal
TRENDS IN IMMUNOLOGY
Volume 40, Issue 5, Pages 431-446Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.03.001
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Funding
- Fonds Wetenschappelijk Onderzoek (FWO) [3G001219]
- Sir Henry Wellcome Fellowship
- Leukemia and Lymphoma Society Fellow award
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ZEB1 and ZEB2 are zinc-finger E homeobox-binding transcription factors best known for their role in driving epithelial to mesenchymal transition. However, in recent years our understanding of these two transcription factors has broadened, and it is now clear that they are expressed by a variety of immune cells of both myeloid and lymphoid lineages, including dendritic cells, macrophages, monocytes, B, T, and NK cells. In these cells, ZEBs function to regulate important transcriptional networks necessary for cell differentiation, maintenance, and function. Here, we review the current understanding of ZEB regulation across immune cell lineages, particularly in mice, highlighting present gaps in our knowledge. We also speculate on important questions for the future.
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