Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 30, Issue 7, Pages 445-458Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2019.05.001
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Funding
- K22 Transition Career Development Award through the National Cancer Institute (NCI)
- Concern Foundation
- V Foundation for Cancer Research
- Hitachi-Nomura Postdoctoral Fellowship through the Department of Biological Chemistry at UC Irvine
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The circadian clock is a biological mechanism that dictates an array of rhythmic physiological processes. Virtually all cells contain a functional clock whose disruption results in altered timekeeping and detrimental systemic effects, including cancer. Recent advances have connected genetic disruption of the clock with multiple transcriptional and signaling networks controlling tumor initiation and progression. An additional feature of this circadian control relies on cellular metabolism, both within the tumor microenvironment and the organism systemically. A discussion of major advances related to cancer metabolism and the circadian clock will be outlined, including new efforts related to metabolic flux of transformed cells, metabolic heterogeneity of tumors, and the implications of circadian control of these pathways.
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