Journal
TRENDS IN CELL BIOLOGY
Volume 29, Issue 7, Pages 591-603Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2019.03.001
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Funding
- ShanghaiTech University [2018F0202-000-06]
- Cancer Research UK [CRUK-A12874]
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The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology of multicellular organisms is far from complete. Here, I review recent advances in the function of APC/C in animal development, specifically focusing on its emerging role in regulating cell differentiation. I describe how APC/C regulates distinct processes during the course of differentiation by deploying diverse molecular machineries in a variety of developmental contexts. Also, I discuss the significance and clinical relevance of the unique capacity of APC/C and other cell cycle regulators to couple distinct cellular processes with cell proliferation control.
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