Journal
TRENDS IN CELL BIOLOGY
Volume 29, Issue 4, Pages 275-276Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2019.02.001
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- NCI NIH HHS [DP2 CA206653] Funding Source: Medline
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Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela et al. (Cell 2019; 176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcription factors, providing novel insights into the epigenetic regulation of 'stemness' in CTC clusters.
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