Journal
TRENDS IN BIOTECHNOLOGY
Volume 37, Issue 11, Pages 1189-1201Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2019.04.004
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Funding
- Australian Research Council [DP150104242]
- Australian Heart Foundation (Future Leader Fellowship) [101896]
- New Zealand Health Research Council (Emerging Researcher First Grant) [15/483]
- New Zealand Health Research Council (Sir Charles Hercus Health Research Fellowship) [19/135]
- Royal Society of New Zealand [MFP-UOO1826, RDF-UOO1204]
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Microchannels are simple, perfusable architectural features engineered into biomaterials to promote mass transport of solutes to cells, effective cell seeding and compartmentalisation for tissue engineering applications, control over spatiotemporal distribution of molecules and ligands, and survival, integration, and vascularisation of engineered tissue analogues in vivo. Advances it biofabrication have led to better control over microchannel fabrication in 3D scaffolds, enabling sophisticated designs that drive the development of complex tissue structures. This review addresses the importance of microchannel structures in biomaterial design and regenerative medicine, and discusses their function, fabrication methods, and proposed mechanisms underlying effects.
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