Journal
TRENDS IN BIOTECHNOLOGY
Volume 37, Issue 10, Pages 1078-1090Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2019.03.016
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Funding
- Research Foundation -Flanders (FWO) [3G050913N]
- Ghent University BOF-GOA grant [2016000602]
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Protein tags have been essential for advancing our knowledge of the function of proteins, their localization, and the mapping of their interaction partners. Expressing epitope-tagged proteins has become a standard practice in every life science laboratory and, thus, continues to enable new studies. In recent years, several new tagging moieties have entered the limelight, many of them bringing new functionalities, such as targeted protein degradation, accurate quantification, and proximity labeling. Other novel tags aim at tackling research questions in challenging niches. In this review, we elaborate on recently introduced tags and the opportunities they provide for future research endeavors. In addition, we highlight how the genome-engineering revolution may boost the field of protein tags.
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