Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 44, Issue 8, Pages 716-728Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2019.03.005
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Funding
- Russian Federation [SP-3665.2018.4]
- Russian Science Foundation [RSCF 18-75-10115, RSCF 19-15-00107]
- Russian Science Foundation [19-15-00107] Funding Source: Russian Science Foundation
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At the turn of this century, cardinal changes took place in the perceptions of the structure and function of proteins, as well as in the organizational principles of membrane-less organelles. As a result, the model of the organization of living matter is changing to one described by highly dynamic biological soft matter positioned at the edge of chaos. Intrinsically disordered proteins (IDPs) and membrane-less organelles are key examples of this new outlook and may represent a critical foundation of life, defining its complexity and the evolution of living things.
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