Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 116, Issue -, Pages 292-299Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2019.04.022
Keywords
Ion mobility spectrometry; Mass spectrometry; Omics; Proteomics; Lipidomics; Metabolomics; Glycomics; Exposomics
Categories
Funding
- NIH National Institute of Environmental Health Sciences [R01 ES022190, P42 ES027704]
- National Institute of General Medical Sciences [P41 GM103493]
- National Institute of Allergy and Infectious Diseases [U19 AI106772]
- National Institute of Child Health and Human Development [R21 HD084788]
- Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory
- U.S. Department of Energy Office of Biological and Environmental Research Genome Sciences Program
- DOE [DE-AC05-76RL0 1830]
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Ion mobility spectrometry (IMS) is a widely used analytical technique providing rapid gas phase separations. IMS alone is useful, but its coupling with mass spectrometry (IMS-MS) and various front-end separation techniques has greatly increased the molecular information achievable from different omic analyses. IMS-MS analyses are specifically gaining attention for improving metabolomic, lipidomic, glycomic, proteomic and exposomic analyses by increasing measurement sensitivity (e.g. S/N ratio), lowering the detection limit, and amplifying peak capacity. Numerous studies including national security-related analyses, disease screenings and environmental evaluations are illustrating that IMS-MS is able to extract information not possible with MS alone. Furthermore, IMS-MS has shown great utility in salvaging molecular information for low abundance molecules of interest when high concentration contaminant ions are present in the sample by reducing detector suppression. This review highlights how IMS-MS is currently being used in omic analyses to distinguish structurally similar molecules, isomers, molecular classes and contaminant ions. (C) 2019 Elsevier B.V. All rights reserved.
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