Journal
TOXIN REVIEWS
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15569543.2019.1614064
Keywords
Scorpion venom; antibacterial peptide; anti-inflammatory; sodium channel
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This study aims to investigate the antimicrobial activity of Androctonus australis hector (Aah) scorpion venom and its nontoxic fraction. Obtained results show that venom inhibits the proliferation of both Gram-positive and Gram-negative bacteria via membrane disruption. The nontoxic fraction is able to reduce bacterial growth, lung damage, and inflammatory profile in a murine model of infection. Proteomic analysis reveals that the antibacterial molecule is a sodium channel inhibitor only automatically annotated by gene model, under the name of G-TI. Herein, is a strict proof existence and a first proteomic characterization of G-TI as an antimicrobial peptide with an anti-inflammatory effect.
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